Lung Mechanics Mechanical Ventilation Lung Poromechanics Multi-fidelity Neural Networks Reduced Order Modeling Dimensionality Reduction

External authors:

• Jose Barahona Yanez ( Pontificia Universidad Catolica de Chile )

Abstract:

Introduction Digital twins of the respiratory system have shown promise in predicting the patient-specific response of lungs connected to mechanical ventilation. However, modeling the spatiotemporal response of the lung tissue through high-fidelity numerical simulations involves computing times that largely exceed those required in clinical applications. In this work, we present a multi-fidelity deep learning surrogate model to efficiently and accurately predict the poromechanical fields that arise in lungs connected to mechanical ventilation.Methods We generate training datasets with two fidelity levels from non-linear finite-element simulations on coarse (low-fidelity) and fine (high-fidelity) discretizations of the lungs domain. Further, we reduce the output spatiotemporal dimensionality using singular value decomposition, capturing over 99% of the variance in both displacement and alveolar pressure fields with only a few principal components. Based on this procedure, we learn both the input-output mappings and fidelity correlations by training a reduced-order multi-fidelity neural network model (rMFNN) that leverages the abundant low-fidelity data to enhance predictions from scarce high-fidelity simulations.Results Compared to a reduced-order single-fidelity neural network (rSFNN) surrogate, the rMFNN achieves superior predictive accuracy in predicting spatiotemporal displacement and alveolar pressure fields (R2 >= 93% (rMFNN) vs R2 >= 75% (rSFNN)). In addition, we show that rMFNN outperforms rSFNN in terms of accuracy for the same level of training cost. Further, the rMFNN model provides inference times of less than a minute, offering speed-ups up to 462x when compared to finite-element numerical simulations.Discussion These results demonstrate the potential of the rMFNN lung model to enable patient-specific predictions in acceptable computing times that can be used to personalize mechanical ventilation therapy in critical patients.