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René Michael Botnar

email rebotnar@uc.cl

Keywords from publications:
Motion Correction Inflammation Congenital Heart Disease Cardiac Mr Free Breathing Atherosclerosis Ver más...

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El Dr. Botnar recibió su doctorado en Ingeniería Biomédica de la ETH de Zúrich.

En 1997 se incorporó al Centro de RM Cardíaca del Centro Médico Beth Israel Deaconess y la Facultad de Medicina de Harvard, que fue uno de los primeros centros de RM centrados específicamente en la RM cardiovascular. Bajo la dirección del Dr. Manning, desarrolló la angiografía coronaria por RM no invasiva de respiración libre como alternativa a la angiografía invasiva por rayos X, que ahora está disponible en la mayoría de los escáneres de RM y se utiliza clínicamente para la detección de cardiopatías congénitas y arterias coronarias anómalas. En 2003 fue nombrado director científico del Centro de RM Cardíaca y en 2004 profesor asistente de medicina en la Facultad de Medicina de Harvard.

En 2005, el Dr. Botnar aceptó una cátedra de Imagen Biomédica en el Departamento de Imagen Nuclear de la Technische Universität München (TUM).

A finales de 2007, se incorporó a la División de Ciencias de la Imagen e Ingeniería Biomédica del King's College de Londres, donde ocupó la cátedra de Imagen Cardiovascular y la dirección del Departamento de Ingeniería Biomédica, y donde puso en marcha un programa de RM cardíaca centrado especialmente en el desarrollo de nuevas secuencias de pulsos de RM, corrección del movimiento y técnicas de imagen cuantitativa para el diagnóstico precoz de enfermedades cardiovasculares.

El Dr. Botnar es miembro de la Sociedad Internacional de Resonancia Magnética en Medicina y de la Sociedad de Resonancia Magnética Cardiovascular y fue presidente del grupo de estudio de RM cardíaca de la ISMRM (2021-22) y de la ESMI (2019-20). Es editor asociado del Journal of Cardiovascular Magnetic Resonance and Molecular Imaging and Biology y ha publicado más de 350 artículos originales relacionadas con la tecnología de RM.

Actualmente es Director y Profesor Titular del Instituto de Ingeniería Biológica y Médica.

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Keywords from publications

Title Year Doi
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group 2023 https://doi.org/10.1038/s41569-023-00880-4
Single-heartbeat cardiac cine imaging via jointly regularized nonrigid motion-corrected reconstruction 2023 https://doi.org/10.1002/nbm.4942
Low-rank motion correction for accelerated free-breathing first-pass myocardial perfusion imaging 2023 https://doi.org/10.1002/mrm.29626
Simultaneous Highly Efficient Contrast-Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease 2023 https://doi.org/10.1002/jmri.28613
Venous Thrombosis Accelerates Atherosclerosis in Mice 2023 https://doi.org/10.1161/CIRCULATIONAHA.123.064268
Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS<SUP>-/-</SUP> mouse model of metabolic nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2023 https://doi.org/10.1002/nbm.4932
Free-running 3D whole-heart T<sub>1</sub> and T<sub>2</sub> mapping and cine MRI using low-rank reconstruction with non-rigid cardiac motion correction 2023 https://doi.org/10.1002/mrm.29449
Optimized Methods for the Surface Immobilization of Collagens and Collagen Binding Assays 2023 https://doi.org/10.3791/64720
MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study 2023 https://doi.org/10.1148/radiol.220736
Quantitative MRI in cardiometabolic disease: From conventional cardiac and liver tissue mapping techniques to multi-parametric approaches 2023 https://doi.org/10.3389/fcvm.2022.991383
Imaging Methods: Magnetic Resonance Imaging 2023 https://doi.org/10.1161/CIRCIMAGING.122.014068
Multi-parametric liver tissue characterization using MR fingerprinting: Simultaneous T-1, T-2, T-2*, and fat fraction mapping 2020 https://doi.org/10.1002/mrm.28311
3D whole-heart isotropic-resolution motion-compensated joint T-1/T(2)mapping and water/fat imaging 2020 https://doi.org/10.1002/mrm.28330
Isotropic 3D Cartesian single breath-hold CINE MRI with multi-bin patch-based low-rank reconstruction 2020 https://doi.org/10.1002/mrm.28267
3D free-breathing cardiac magnetic resonance fingerprinting 2020 https://doi.org/10.1002/nbm.4370
Free-running simultaneous myocardial T1/T2 mapping and cine imaging with 3D whole-heart coverage and isotropic spatial resolution 2019 https://doi.org/10.1016/j.mri.2019.08.008
3D Cartesian fast interrupted steady-state (FISS) imaging 2019 https://doi.org/10.1002/mrm.27830
Free-running 3D whole heart myocardial T-1 mapping with isotropic spatial resolution 2019 https://doi.org/10.1002/mrm.27811
A multi-scale variational neural network for accelerating motion-compensated whole-heart 3D coronary MR angiography 2020 https://doi.org/10.1016/j.mri.2020.04.007
Whole-heart T-1 mapping using a 2D fat image navigator for respiratory motion compensation 2020 https://doi.org/10.1002/mrm.27919
Accelerated free-breathing whole-heart 3D T-2 mapping with high isotropic resolution 2020 https://doi.org/10.1002/mrm.27989
3D Whole-heart free-breathing qBOOST-T2 mapping 2020 https://doi.org/10.1002/mrm.28039
Water-fat Dixon cardiac magnetic resonance fingerprinting 2020 https://doi.org/10.1002/mrm.28070
Faster 3D saturation-recovery based myocardial T1 mapping using a reduced number of saturation points and denoising 2020 https://doi.org/10.1371/journal.pone.0221071
Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T(2)prep-IR 2019 https://doi.org/10.1002/mrm.27734
Motion corrected water/fat whole-heart coronary MR angiography with 100% respiratory efficiency 2019 https://doi.org/10.1002/mrm.27732
3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST 2020 https://doi.org/10.1186/s12968-020-00611-5
Free-running cardiac magnetic resonance fingerprinting: Joint T1/T2 map and Cine imaging 2020 https://doi.org/10.1016/j.mri.2020.02.005
From Compressed-Sensing to Artificial Intelligence-Based Cardiac MRI Reconstruction 2020 https://doi.org/10.3389/fcvm.2020.00017
Respiratory motion-compensated high-resolution 3D whole-heart T1 rho mapping 2020 https://doi.org/10.1186/s12968-020-0597-5
High-dimensionality undersampled patch-based reconstruction (HD-PROST) for accelerated multi-contrast MRI 2019 https://doi.org/10.1002/mrm.27694
Sparsity and locally low rank regularization for MR fingerprinting 2019 https://doi.org/10.1002/mrm.27665
Respiratory- and cardiac motion-corrected simultaneous whole-heart PET and dual phase coronary MR angiography 2019 https://doi.org/10.1002/mrm.27517
Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging 2019 https://doi.org/10.1161/ATVBAHA.118.311754
Rigid motion-corrected magnetic resonance fingerprinting 2019 https://doi.org/10.1002/mrm.27448
Non-contrast enhanced simultaneous 3D whole-heart bright-blood pulmonary veins visualization and black-blood quantification of atrial wall thickness 2019 https://doi.org/10.1002/mrm.27472
Cardiac Magnetic Resonance Fingerprinting: Technical Developments and Initial Clinical Validation 2019 https://doi.org/10.1007/s11886-019-1181-1
Five-minute whole-heart coronary MRA with sub-millimeter isotropic resolution, 100% respiratory scan efficiency, and 3D-PROST reconstruction 2019 https://doi.org/10.1002/mrm.27354
Optimized respiratory-resolved motion-compensated 3D Cartesian coronary MR angiography 2018 https://doi.org/10.1002/mrm.27208
3D SASHA myocardial T1 mapping with high accuracy and improved precision 2019 https://doi.org/10.1007/s10334-018-0703-y
Accelerated magnetic resonance fingerprinting using soft-weighted key-hole (MRF-SOHO) 2018 https://doi.org/10.1371/journal.pone.0201808
3D SASHA myocardial T1 mapping with high accuracy and improved precision (vol 32, pg 281, 2019) 2019 https://doi.org/10.1007/s10334-018-0706-8
Motion-corrected simultaneous cardiac positron emission tomography and coronary MR angiography with high acquisition efficiency 2018 https://doi.org/10.1002/mrm.26690
Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation 2018 https://doi.org/10.1007/s00259-018-4047-7
Technical note: Accelerated nonrigid motion-compensated isotropic 3D coronary MR angiography 2018 https://doi.org/10.1002/mp.12663
Simultaneous bright- and black-blood whole-heart MRI for noncontrast enhanced coronary lumen and thrombus visualization 2018 https://doi.org/10.1002/mrm.26815
Latest Advances in Image Acceleration: All Dimensions are Fair Game 2022 https://doi.org/10.1002/jmri.28462
End-to-end deep learning nonrigid motion-corrected reconstruction for highly accelerated free-breathing coronary MRA 2021 https://doi.org/10.1002/mrm.28851
Deep-learning based super-resolution for 3D isotropic coronary MR angiography in less than a minute 2021 https://doi.org/10.1002/mrm.28911
Generalized low-rank nonrigid motion-corrected reconstruction for MR fingerprinting 2022 https://doi.org/10.1002/mrm.29027
Simultaneous T-1, T-2, and T-1 rho cardiac magnetic resonance fingerprinting for contrast agent-free myocardial tissue characterization 2022 https://doi.org/10.1002/mrm.29091
Myocardial T1, T2, T2*, and fat fraction quantification via low-rank motion-corrected cardiac MR fingerprinting 2022 https://doi.org/10.1002/mrm.29171
Accelerated 3D free-breathing high-resolution myocardial T-1 rho mapping at 3 Tesla 2022 https://doi.org/10.1002/mrm.29417
Accelerating 3D MTC-BOOST in patients with congenital heart disease using a joint multi-scale variational neural network reconstruction 2022 https://doi.org/10.1016/j.mri.2022.06.012
Self-supervised learning-based diffeomorphic non-rigid motion estimation for fast motion-compensated coronary MR angiography 2022 https://doi.org/10.1016/j.mri.2021.10.004
Simultaneous comprehensive liver T-1, T-2, T-2*,T- (1 rho), and fat fraction characterization with MR fingerprinting 2022 https://doi.org/10.1002/mrm.29089
Artificial intelligence in cardiac magnetic resonance fingerprinting 2022 https://doi.org/10.3389/fcvm.2022.1009131
Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting 2022 https://doi.org/10.1007/s00330-022-08560-6
High-resolution non-contrast free-breathing coronary cardiovascular magnetic resonance ngiography for detection of coronary artery disease: validation against invasive coronary angiography 2022 https://doi.org/10.1186/s12968-022-00858-0
Artificial Intelligence in Cardiac MRI: Is Clinical Adoption Forthcoming? 2022 https://doi.org/10.3389/fcvm.2021.818765
Whole-heart non-rigid motion corrected coronary MRA with autofocus virtual 3D iNAV 2022 https://doi.org/10.1016/j.mri.2022.01.007
MRI-Guided Motion-Corrected PET Image Reconstruction for Cardiac PET/MRI 2021 https://doi.org/10.2967/jnumed.120.254235
Efficient non-contrast enhanced 3D Cartesian cardiovascular magnetic resonance angiography of the thoracic aorta in 3 min 2022 https://doi.org/10.1186/s12968-021-00839-9
Evaluation of accelerated motion-compensated 3d water/fat late gadolinium enhanced MR for atrial wall imaging 2021 https://doi.org/10.1007/s10334-021-00935-y
Coronary Magnetic Resonance Angiography in Chronic Coronary Syndromes 2021 https://doi.org/10.3389/fcvm.2021.682924
3D whole-heart grey-blood late gadolinium enhancement cardiovascular magnetic resonance imaging 2021 https://doi.org/10.1186/s12968-021-00751-2
Clinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial 2021 https://doi.org/10.1186/s12968-021-00758-9
Synergistic multi-contrast cardiac magnetic resonance image reconstruction 2021 https://doi.org/10.1098/rsta.2020.0197
Coronary Magnetic Resonance Angiography Technical Innovations Leading Us to the Promised Land? 2020 https://doi.org/10.1016/j.jcmg.2020.01.006
Accelerated high-resolution free-breathing 3D whole-heart T-2-prepared black-blood and bright-blood cardiovascular magnetic resonance 2020 https://doi.org/10.1186/s12968-020-00691-3
CINENet: deep learning-based 3D cardiac CINE MRI reconstruction with multi-coil complex-valued 4D spatio-temporal convolutions 2020 https://doi.org/10.1038/s41598-020-70551-8
PET/MRI of atherosclerosis 2020 https://doi.org/10.21037/cdt.2020.02.09
KomaMRI.jl: An open-source framework for general MRI simulations with GPU acceleration 2023 https://doi.org/10.1002/mrm.29635
Automated detection of cardiac rest period for trigger delay calculation for image-based navigator coronary magnetic resonance angiography 2023 https://doi.org/10.1186/s12968-023-00962-9
Free-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease 2023 https://doi.org/10.1148/ryct.220146
Use of a new non-contrast-enhanced BOOST cardiac MR sequence before electrical cardioversion or ablation of atrial fibrillation-a pilot study 2023 https://doi.org/10.3389/fcvm.2023.1177347
UNDERSTANDING THE ROLE OF CARDIAC FIBROSIS IN THE DEVELOPMENT AND TREATMENT OF HEART FAILURE USING MOLECULAR IMAGING PROBES AND NOVEL THERAPEUTICS 2023 https://doi.org/10.1136/heartjnl-2023-BCS.299
MR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions 2023 https://doi.org/10.1148/rycan.230036
Non-rigid motion-compensated 3D whole-heart T<sub>2</sub> mapping in a hybrid 3T PET-MR system 2024 https://doi.org/10.1002/mrm.29973
Self-Supervised Motion-Corrected Image Reconstruction Network for 4D Magnetic Resonance Imaging of the Body Trunk 2022 https://doi.org/10.1561/116.00000039
High-Spatial-Resolution 3D Whole-Heart MRI T2 Mapping for Assessment of Myocarditis 2021 https://doi.org/10.1148/radiol.2021201630
Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods 2022 https://doi.org/10.1055/a-1718-4355
Quantitative MRI of Endothelial Permeability and (Dys)function in Atherosclerosis 2021 https://doi.org/10.3791/62724
Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization<SUP> </SUP> 2022 https://doi.org/10.1093/ehjci/jeab276
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries 2022 https://doi.org/10.1038/s41467-022-30464-8
Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy 2021 https://doi.org/10.1016/j.aohep.2021.100358
Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin 2021 https://doi.org/10.1021/acs.jmedchem.1c01286
Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging 2021 https://doi.org/10.3390/biology10100964
In vivo assessment of endothelial permeability of coronary lesions with variable degree of stenosis using an albumin-binding MR probe 2021 https://doi.org/10.1007/s10554-021-02293-1
Dark-blood late gadolinium enhancement cardiovascular magnetic resonance for improved detection of subendocardial scar: a review of current techniques 2021 https://doi.org/10.1186/s12968-021-00777-6
Tropoelastin: an <i>in vivo</i> imaging marker of dysfunctional matrix turnover during abdominal aortic dilation 2020 https://doi.org/10.1093/cvr/cvz178
Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm 2020 https://doi.org/10.1177/1536012120961875
Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture 2020 https://doi.org/10.1038/s41598-020-71817-x
Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries 2020 https://doi.org/10.1161/ATVBAHA.120.314387
Imaging the Extracellular Matrix in Prevalent Cardiovascular Diseases 2020 https://doi.org/10.3390/app10114001
Dual-probe molecular MRI for the <i>in vivo</i> characterization of atherosclerosis in a mouse model: <i>Simultaneous assessment of plaque inflammation and extracellular</i>-<i>matrix remodeling</i> 2019 https://doi.org/10.1038/s41598-019-50100-8
Clinical value of dark-blood late gadolinium enhancement cardiovascular magnetic resonance without additional magnetization preparation 2019 https://doi.org/10.1186/s12968-019-0556-1
Imaging sequence for joint myocardial T<sub>1</sub> mapping and fat/water separation 2019 https://doi.org/10.1002/mrm.27390
Molecular Imaging in Ischemic Heart Disease 2019 https://doi.org/10.1007/s12410-019-9500-x
Concurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture 2019 https://doi.org/10.1161/CIRCIMAGING.118.008707
Noninvasive Imaging of Endothelial Damage in Patients With Different HbA<sub>1c</sub> Levels: A Proof-of-Concept Study 2019 https://doi.org/10.2337/db18-0239
Inversion recovery and saturation recovery pulmonary vein MR angiography using an image based navigator fluoro trigger and variable-density 3D cartesian sampling with spiral-like order 2024 https://doi.org/10.1007/s10554-024-03111-0
Extended MRI-based PET motion correction for cardiac PET/MRI 2024 https://doi.org/10.1186/s40658-024-00637-z
Highly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease 2024 https://doi.org/10.1016/j.jocmr.2023.100008
Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance 2024 https://doi.org/10.1038/s41598-024-52058-8
A motion-corrected deep-learning reconstruction framework for accelerating whole-heart magnetic resonance imaging in patients with congenital heart disease 2024 https://doi.org/10.1016/j.jocmr.2024.101039
KomaMRI.jl: An Open-Source Framework for General MRI Simulations with GPU Acceleration 2023 https://doi.org/arXiv:2301.02702
Free-breathing 3D whole-heart joint T<sub>1</sub>/T<sub>2</sub> mapping and water/fat imaging at 0.55 T 2024 https://doi.org/10.1002/mrm.30139
Clinical impact of novel cardiovascular magnetic resonance technology on patients with congenital heart disease: a scientific statement of the Association for European Pediatric and Congenital Cardiology and the European Association of Cardiovascular Imaging of the European Society of Cardiology 2024 https://doi.org/10.1093/ehjci/jeae172
Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T 2024 https://doi.org/10.1002/mrm.30316
Evaluation of myocarditis with a free-breathing three-dimensional isotropic whole-heart joint T1 and T2 mapping sequence 2024 https://doi.org/10.1016/j.jocmr.2024.101100
3D B1+corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation 2024 https://doi.org/10.1002/mrm.30317
Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease 2024 https://doi.org/10.1007/s00392-024-02503-5
Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis 2024 https://doi.org/10.1038/s41598-024-71716-5

School Co-Authors

  • Carlos Alberto Sing-long
    1 publication

* Authors who are no longer vigent are not clickable.

External Co-Authors

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