
René Michael Botnar
email rebotnar@uc.cl
Keywords from publications:
Motion Correction Inflammation Congenital Heart Disease Cardiac Mr Free Breathing Atherosclerosis Ver más...Profile
El Dr. Botnar recibió su doctorado en Ingeniería Biomédica de la ETH de Zúrich.
En 1997 se incorporó al Centro de RM Cardíaca del Centro Médico Beth Israel Deaconess y la Facultad de Medicina de Harvard, que fue uno de los primeros centros de RM centrados específicamente en la RM cardiovascular. Bajo la dirección del Dr. Manning, desarrolló la angiografía coronaria por RM no invasiva de respiración libre como alternativa a la angiografía invasiva por rayos X, que ahora está disponible en la mayoría de los escáneres de RM y se utiliza clínicamente para la detección de cardiopatías congénitas y arterias coronarias anómalas. En 2003 fue nombrado director científico del Centro de RM Cardíaca y en 2004 profesor asistente de medicina en la Facultad de Medicina de Harvard.
En 2005, el Dr. Botnar aceptó una cátedra de Imagen Biomédica en el Departamento de Imagen Nuclear de la Technische Universität München (TUM).
A finales de 2007, se incorporó a la División de Ciencias de la Imagen e Ingeniería Biomédica del King's College de Londres, donde ocupó la cátedra de Imagen Cardiovascular y la dirección del Departamento de Ingeniería Biomédica, y donde puso en marcha un programa de RM cardíaca centrado especialmente en el desarrollo de nuevas secuencias de pulsos de RM, corrección del movimiento y técnicas de imagen cuantitativa para el diagnóstico precoz de enfermedades cardiovasculares.
El Dr. Botnar es miembro de la Sociedad Internacional de Resonancia Magnética en Medicina y de la Sociedad de Resonancia Magnética Cardiovascular y fue presidente del grupo de estudio de RM cardíaca de la ISMRM (2021-22) y de la ESMI (2019-20). Es editor asociado del Journal of Cardiovascular Magnetic Resonance and Molecular Imaging and Biology y ha publicado más de 350 artículos originales relacionadas con la tecnología de RM.
Actualmente es Director y Profesor Titular del Instituto de Ingeniería Biológica y Médica.
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Keywords from publications
Title | Year | Doi |
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Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group | 2023 | https://doi.org/10.1038/s41569-023-00880-4 |
Single-heartbeat cardiac cine imaging via jointly regularized nonrigid motion-corrected reconstruction | 2023 | https://doi.org/10.1002/nbm.4942 |
Low-rank motion correction for accelerated free-breathing first-pass myocardial perfusion imaging | 2023 | https://doi.org/10.1002/mrm.29626 |
Simultaneous Highly Efficient Contrast-Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease | 2023 | https://doi.org/10.1002/jmri.28613 |
Venous Thrombosis Accelerates Atherosclerosis in Mice | 2023 | https://doi.org/10.1161/CIRCULATIONAHA.123.064268 |
Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS<SUP>-/-</SUP> mouse model of metabolic nonalcoholic fatty liver disease/nonalcoholic steatohepatitis | 2023 | https://doi.org/10.1002/nbm.4932 |
Free-running 3D whole-heart T<sub>1</sub> and T<sub>2</sub> mapping and cine MRI using low-rank reconstruction with non-rigid cardiac motion correction | 2023 | https://doi.org/10.1002/mrm.29449 |
Optimized Methods for the Surface Immobilization of Collagens and Collagen Binding Assays | 2023 | https://doi.org/10.3791/64720 |
MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study | 2023 | https://doi.org/10.1148/radiol.220736 |
Quantitative MRI in cardiometabolic disease: From conventional cardiac and liver tissue mapping techniques to multi-parametric approaches | 2023 | https://doi.org/10.3389/fcvm.2022.991383 |
Imaging Methods: Magnetic Resonance Imaging | 2023 | https://doi.org/10.1161/CIRCIMAGING.122.014068 |
Multi-parametric liver tissue characterization using MR fingerprinting: Simultaneous T-1, T-2, T-2*, and fat fraction mapping | 2020 | https://doi.org/10.1002/mrm.28311 |
3D whole-heart isotropic-resolution motion-compensated joint T-1/T(2)mapping and water/fat imaging | 2020 | https://doi.org/10.1002/mrm.28330 |
Isotropic 3D Cartesian single breath-hold CINE MRI with multi-bin patch-based low-rank reconstruction | 2020 | https://doi.org/10.1002/mrm.28267 |
3D free-breathing cardiac magnetic resonance fingerprinting | 2020 | https://doi.org/10.1002/nbm.4370 |
Free-running simultaneous myocardial T1/T2 mapping and cine imaging with 3D whole-heart coverage and isotropic spatial resolution | 2019 | https://doi.org/10.1016/j.mri.2019.08.008 |
3D Cartesian fast interrupted steady-state (FISS) imaging | 2019 | https://doi.org/10.1002/mrm.27830 |
Free-running 3D whole heart myocardial T-1 mapping with isotropic spatial resolution | 2019 | https://doi.org/10.1002/mrm.27811 |
A multi-scale variational neural network for accelerating motion-compensated whole-heart 3D coronary MR angiography | 2020 | https://doi.org/10.1016/j.mri.2020.04.007 |
Whole-heart T-1 mapping using a 2D fat image navigator for respiratory motion compensation | 2020 | https://doi.org/10.1002/mrm.27919 |
Accelerated free-breathing whole-heart 3D T-2 mapping with high isotropic resolution | 2020 | https://doi.org/10.1002/mrm.27989 |
3D Whole-heart free-breathing qBOOST-T2 mapping | 2020 | https://doi.org/10.1002/mrm.28039 |
Water-fat Dixon cardiac magnetic resonance fingerprinting | 2020 | https://doi.org/10.1002/mrm.28070 |
Faster 3D saturation-recovery based myocardial T1 mapping using a reduced number of saturation points and denoising | 2020 | https://doi.org/10.1371/journal.pone.0221071 |
Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T(2)prep-IR | 2019 | https://doi.org/10.1002/mrm.27734 |
Motion corrected water/fat whole-heart coronary MR angiography with 100% respiratory efficiency | 2019 | https://doi.org/10.1002/mrm.27732 |
3D whole-heart isotropic sub-millimeter resolution coronary magnetic resonance angiography with non-rigid motion-compensated PROST | 2020 | https://doi.org/10.1186/s12968-020-00611-5 |
Free-running cardiac magnetic resonance fingerprinting: Joint T1/T2 map and Cine imaging | 2020 | https://doi.org/10.1016/j.mri.2020.02.005 |
From Compressed-Sensing to Artificial Intelligence-Based Cardiac MRI Reconstruction | 2020 | https://doi.org/10.3389/fcvm.2020.00017 |
Respiratory motion-compensated high-resolution 3D whole-heart T1 rho mapping | 2020 | https://doi.org/10.1186/s12968-020-0597-5 |
High-dimensionality undersampled patch-based reconstruction (HD-PROST) for accelerated multi-contrast MRI | 2019 | https://doi.org/10.1002/mrm.27694 |
Sparsity and locally low rank regularization for MR fingerprinting | 2019 | https://doi.org/10.1002/mrm.27665 |
Respiratory- and cardiac motion-corrected simultaneous whole-heart PET and dual phase coronary MR angiography | 2019 | https://doi.org/10.1002/mrm.27517 |
Molecular and Nonmolecular Magnetic Resonance Coronary and Carotid Imaging | 2019 | https://doi.org/10.1161/ATVBAHA.118.311754 |
Rigid motion-corrected magnetic resonance fingerprinting | 2019 | https://doi.org/10.1002/mrm.27448 |
Non-contrast enhanced simultaneous 3D whole-heart bright-blood pulmonary veins visualization and black-blood quantification of atrial wall thickness | 2019 | https://doi.org/10.1002/mrm.27472 |
Cardiac Magnetic Resonance Fingerprinting: Technical Developments and Initial Clinical Validation | 2019 | https://doi.org/10.1007/s11886-019-1181-1 |
Five-minute whole-heart coronary MRA with sub-millimeter isotropic resolution, 100% respiratory scan efficiency, and 3D-PROST reconstruction | 2019 | https://doi.org/10.1002/mrm.27354 |
Optimized respiratory-resolved motion-compensated 3D Cartesian coronary MR angiography | 2018 | https://doi.org/10.1002/mrm.27208 |
3D SASHA myocardial T1 mapping with high accuracy and improved precision | 2019 | https://doi.org/10.1007/s10334-018-0703-y |
Accelerated magnetic resonance fingerprinting using soft-weighted key-hole (MRF-SOHO) | 2018 | https://doi.org/10.1371/journal.pone.0201808 |
3D SASHA myocardial T1 mapping with high accuracy and improved precision (vol 32, pg 281, 2019) | 2019 | https://doi.org/10.1007/s10334-018-0706-8 |
Motion-corrected simultaneous cardiac positron emission tomography and coronary MR angiography with high acquisition efficiency | 2018 | https://doi.org/10.1002/mrm.26690 |
Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation | 2018 | https://doi.org/10.1007/s00259-018-4047-7 |
Technical note: Accelerated nonrigid motion-compensated isotropic 3D coronary MR angiography | 2018 | https://doi.org/10.1002/mp.12663 |
Simultaneous bright- and black-blood whole-heart MRI for noncontrast enhanced coronary lumen and thrombus visualization | 2018 | https://doi.org/10.1002/mrm.26815 |
Latest Advances in Image Acceleration: All Dimensions are Fair Game | 2022 | https://doi.org/10.1002/jmri.28462 |
End-to-end deep learning nonrigid motion-corrected reconstruction for highly accelerated free-breathing coronary MRA | 2021 | https://doi.org/10.1002/mrm.28851 |
Deep-learning based super-resolution for 3D isotropic coronary MR angiography in less than a minute | 2021 | https://doi.org/10.1002/mrm.28911 |
Generalized low-rank nonrigid motion-corrected reconstruction for MR fingerprinting | 2022 | https://doi.org/10.1002/mrm.29027 |
Simultaneous T-1, T-2, and T-1 rho cardiac magnetic resonance fingerprinting for contrast agent-free myocardial tissue characterization | 2022 | https://doi.org/10.1002/mrm.29091 |
Myocardial T1, T2, T2*, and fat fraction quantification via low-rank motion-corrected cardiac MR fingerprinting | 2022 | https://doi.org/10.1002/mrm.29171 |
Accelerated 3D free-breathing high-resolution myocardial T-1 rho mapping at 3 Tesla | 2022 | https://doi.org/10.1002/mrm.29417 |
Accelerating 3D MTC-BOOST in patients with congenital heart disease using a joint multi-scale variational neural network reconstruction | 2022 | https://doi.org/10.1016/j.mri.2022.06.012 |
Self-supervised learning-based diffeomorphic non-rigid motion estimation for fast motion-compensated coronary MR angiography | 2022 | https://doi.org/10.1016/j.mri.2021.10.004 |
Simultaneous comprehensive liver T-1, T-2, T-2*,T- (1 rho), and fat fraction characterization with MR fingerprinting | 2022 | https://doi.org/10.1002/mrm.29089 |
Artificial intelligence in cardiac magnetic resonance fingerprinting | 2022 | https://doi.org/10.3389/fcvm.2022.1009131 |
Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting | 2022 | https://doi.org/10.1007/s00330-022-08560-6 |
High-resolution non-contrast free-breathing coronary cardiovascular magnetic resonance ngiography for detection of coronary artery disease: validation against invasive coronary angiography | 2022 | https://doi.org/10.1186/s12968-022-00858-0 |
Artificial Intelligence in Cardiac MRI: Is Clinical Adoption Forthcoming? | 2022 | https://doi.org/10.3389/fcvm.2021.818765 |
Whole-heart non-rigid motion corrected coronary MRA with autofocus virtual 3D iNAV | 2022 | https://doi.org/10.1016/j.mri.2022.01.007 |
MRI-Guided Motion-Corrected PET Image Reconstruction for Cardiac PET/MRI | 2021 | https://doi.org/10.2967/jnumed.120.254235 |
Efficient non-contrast enhanced 3D Cartesian cardiovascular magnetic resonance angiography of the thoracic aorta in 3 min | 2022 | https://doi.org/10.1186/s12968-021-00839-9 |
Evaluation of accelerated motion-compensated 3d water/fat late gadolinium enhanced MR for atrial wall imaging | 2021 | https://doi.org/10.1007/s10334-021-00935-y |
Coronary Magnetic Resonance Angiography in Chronic Coronary Syndromes | 2021 | https://doi.org/10.3389/fcvm.2021.682924 |
3D whole-heart grey-blood late gadolinium enhancement cardiovascular magnetic resonance imaging | 2021 | https://doi.org/10.1186/s12968-021-00751-2 |
Clinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial | 2021 | https://doi.org/10.1186/s12968-021-00758-9 |
Synergistic multi-contrast cardiac magnetic resonance image reconstruction | 2021 | https://doi.org/10.1098/rsta.2020.0197 |
Coronary Magnetic Resonance Angiography Technical Innovations Leading Us to the Promised Land? | 2020 | https://doi.org/10.1016/j.jcmg.2020.01.006 |
Accelerated high-resolution free-breathing 3D whole-heart T-2-prepared black-blood and bright-blood cardiovascular magnetic resonance | 2020 | https://doi.org/10.1186/s12968-020-00691-3 |
CINENet: deep learning-based 3D cardiac CINE MRI reconstruction with multi-coil complex-valued 4D spatio-temporal convolutions | 2020 | https://doi.org/10.1038/s41598-020-70551-8 |
PET/MRI of atherosclerosis | 2020 | https://doi.org/10.21037/cdt.2020.02.09 |
KomaMRI.jl: An open-source framework for general MRI simulations with GPU acceleration | 2023 | https://doi.org/10.1002/mrm.29635 |
Automated detection of cardiac rest period for trigger delay calculation for image-based navigator coronary magnetic resonance angiography | 2023 | https://doi.org/10.1186/s12968-023-00962-9 |
Free-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease | 2023 | https://doi.org/10.1148/ryct.220146 |
Use of a new non-contrast-enhanced BOOST cardiac MR sequence before electrical cardioversion or ablation of atrial fibrillation-a pilot study | 2023 | https://doi.org/10.3389/fcvm.2023.1177347 |
UNDERSTANDING THE ROLE OF CARDIAC FIBROSIS IN THE DEVELOPMENT AND TREATMENT OF HEART FAILURE USING MOLECULAR IMAGING PROBES AND NOVEL THERAPEUTICS | 2023 | https://doi.org/10.1136/heartjnl-2023-BCS.299 |
MR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions | 2023 | https://doi.org/10.1148/rycan.230036 |
Non-rigid motion-compensated 3D whole-heart T<sub>2</sub> mapping in a hybrid 3T PET-MR system | 2024 | https://doi.org/10.1002/mrm.29973 |
Self-Supervised Motion-Corrected Image Reconstruction Network for 4D Magnetic Resonance Imaging of the Body Trunk | 2022 | https://doi.org/10.1561/116.00000039 |
High-Spatial-Resolution 3D Whole-Heart MRI T2 Mapping for Assessment of Myocarditis | 2021 | https://doi.org/10.1148/radiol.2021201630 |
Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods | 2022 | https://doi.org/10.1055/a-1718-4355 |
Quantitative MRI of Endothelial Permeability and (Dys)function in Atherosclerosis | 2021 | https://doi.org/10.3791/62724 |
Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization<SUP> </SUP> | 2022 | https://doi.org/10.1093/ehjci/jeab276 |
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries | 2022 | https://doi.org/10.1038/s41467-022-30464-8 |
Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy | 2021 | https://doi.org/10.1016/j.aohep.2021.100358 |
Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin | 2021 | https://doi.org/10.1021/acs.jmedchem.1c01286 |
Assessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging | 2021 | https://doi.org/10.3390/biology10100964 |
In vivo assessment of endothelial permeability of coronary lesions with variable degree of stenosis using an albumin-binding MR probe | 2021 | https://doi.org/10.1007/s10554-021-02293-1 |
Dark-blood late gadolinium enhancement cardiovascular magnetic resonance for improved detection of subendocardial scar: a review of current techniques | 2021 | https://doi.org/10.1186/s12968-021-00777-6 |
Tropoelastin: an <i>in vivo</i> imaging marker of dysfunctional matrix turnover during abdominal aortic dilation | 2020 | https://doi.org/10.1093/cvr/cvz178 |
Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm | 2020 | https://doi.org/10.1177/1536012120961875 |
Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture | 2020 | https://doi.org/10.1038/s41598-020-71817-x |
Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries | 2020 | https://doi.org/10.1161/ATVBAHA.120.314387 |
Imaging the Extracellular Matrix in Prevalent Cardiovascular Diseases | 2020 | https://doi.org/10.3390/app10114001 |
Dual-probe molecular MRI for the <i>in vivo</i> characterization of atherosclerosis in a mouse model: <i>Simultaneous assessment of plaque inflammation and extracellular</i>-<i>matrix remodeling</i> | 2019 | https://doi.org/10.1038/s41598-019-50100-8 |
Clinical value of dark-blood late gadolinium enhancement cardiovascular magnetic resonance without additional magnetization preparation | 2019 | https://doi.org/10.1186/s12968-019-0556-1 |
Imaging sequence for joint myocardial T<sub>1</sub> mapping and fat/water separation | 2019 | https://doi.org/10.1002/mrm.27390 |
Molecular Imaging in Ischemic Heart Disease | 2019 | https://doi.org/10.1007/s12410-019-9500-x |
Concurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture | 2019 | https://doi.org/10.1161/CIRCIMAGING.118.008707 |
Noninvasive Imaging of Endothelial Damage in Patients With Different HbA<sub>1c</sub> Levels: A Proof-of-Concept Study | 2019 | https://doi.org/10.2337/db18-0239 |
Inversion recovery and saturation recovery pulmonary vein MR angiography using an image based navigator fluoro trigger and variable-density 3D cartesian sampling with spiral-like order | 2024 | https://doi.org/10.1007/s10554-024-03111-0 |
Extended MRI-based PET motion correction for cardiac PET/MRI | 2024 | https://doi.org/10.1186/s40658-024-00637-z |
Highly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease | 2024 | https://doi.org/10.1016/j.jocmr.2023.100008 |
Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance | 2024 | https://doi.org/10.1038/s41598-024-52058-8 |
A motion-corrected deep-learning reconstruction framework for accelerating whole-heart magnetic resonance imaging in patients with congenital heart disease | 2024 | https://doi.org/10.1016/j.jocmr.2024.101039 |
KomaMRI.jl: An Open-Source Framework for General MRI Simulations with GPU Acceleration | 2023 | https://doi.org/arXiv:2301.02702 |
Free-breathing 3D whole-heart joint T<sub>1</sub>/T<sub>2</sub> mapping and water/fat imaging at 0.55 T | 2024 | https://doi.org/10.1002/mrm.30139 |
Clinical impact of novel cardiovascular magnetic resonance technology on patients with congenital heart disease: a scientific statement of the Association for European Pediatric and Congenital Cardiology and the European Association of Cardiovascular Imaging of the European Society of Cardiology | 2024 | https://doi.org/10.1093/ehjci/jeae172 |
Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T | 2024 | https://doi.org/10.1002/mrm.30316 |
Evaluation of myocarditis with a free-breathing three-dimensional isotropic whole-heart joint T1 and T2 mapping sequence | 2024 | https://doi.org/10.1016/j.jocmr.2024.101100 |
3D B1+corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation | 2024 | https://doi.org/10.1002/mrm.30317 |
Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease | 2024 | https://doi.org/10.1007/s00392-024-02503-5 |
Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis | 2024 | https://doi.org/10.1038/s41598-024-71716-5 |
School Co-Authors
- 21 publications
- 2 publications
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Carlos Alberto Sing-long1 publication
* Authors who are no longer vigent are not clickable.
External Co-Authors
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Karl Kunze10 publications
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Tevfik F. Ismail4 publications
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Carlos Velasco4 publications
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Michaela Schmidt2 publications
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